The Supel™ Carbon from Supelco™ (Merck) are based on porous graphitic carbon (PGC). These particles have a unique retention mechanism, that can retain polar compounds using reversed-phase chromatography conditions. Moreover, the resolution of isomers is possible. Supel Carbon HPLC-Columns are compatible with any polar and non-polar solvent. Furthermore, this series can be used at pH values between 1 and 14 at temperatures up to 250 °C. They are stable at pressures up to 700 bar.